Azit® 250 / 500 mg For The Treatment of Various Bacterial Infections – Overview
Gram-positive cocci are sensitive to Azit®; Streptococcus pneumoniae, St.piogenes, St.agalactiae, streptococci of groups C, F and G, St.viridans, Staphylococcus aureus; gram-negative bacteria; Hacmophilus influenzae, Moraxella catarrhalis, Bordetella perrtussis, B. parapertussis, Legionella pneumopnila, H.ducrei, Campylobacter jejuni, Neisseria gonorrhoeae and Gardnerella vaginatis; some anaerobic microorganisms: Bacteroides bivius, Closiridium perfringens, Peptostreptococcus spp; as well as Chlamydia trachomatis, Mycoplasma pneumoniae, Ureaplasma urealyticum, Treponema pallidum, Borrelia burgdoferi.
Azit® is inactive against gram-positive bacteria resistant to erythromycin.
Azit® Azithromycin penetrates well into the respiratory tract, organs and tissues of the urogenital tract (in particular, the prostate gland), skin and soft tissues. The high concentration in tissues (10-15 times higher than in blood plasma) and the long half-life are due to the low binding of azithromycin to plasma proteins, as well as its ability to penetrate eukaryotic cells and concentrate in a low pH environment surrounding lysosomes. This, in turn, determines the large apparent volume of distribution (31.1 l/kg) and high plasma clearance.
The ability of azithromycin accumulates, mainly in lysosomes, is especially important for the elimination of intracellular pathogens. It has been proven that phagocytes deliver azithromycin to the sites of infection localization, where it is released during phagocytosis. https://stromectol-ivermectin.us The concentration of azithromycin in the foci of infection is significantly higher than in healthy tissues (on average by 24-34%) and correlates with the degree of inflammatory edema. Despite the high concentration in phagocytes, azithromycin does not significantly affect their function.
Azithromycin remains in bactericidal concentrations in the focus of inflammation for 5-7 days after taking the last dose, which made it possible to develop short (3-day and 5-day) courses of treatment.
How should azithromycin drug Azit® be used?
Presentation of azithromycin in tablets, suspension (liquid) with prolonged release (long-acting) and suspension (liquid) for oral administration. Tablets and suspension (Zithromax) are usually taken with or without food once a day for 1 to 5 days. Azithromycin Azit® tablets are usually taken with or without food once a week when used to prevent a common MAC infection, a prolonged-release suspension (Zmax) is usually taken as a single dose on an empty stomach (at least 1 hour before or 2 hours after a meal). To help you remember to take Azit® Azithromycin, take the medicine at about the same time every day. Carefully follow the instructions on the label of your prescription medication and ask your doctor or pharmacist to explain everything you don’t understand. Take Azit® exactly as you were told. Do not take more or less medication and do not take it more often than the doctor says.
Shake the liquid well before each use to mix the medicine evenly. Use a measuring spoon, an oral medicine syringe, or a measuring cup to measure the correct amount of medication. Rinse with water everything you used to measure after taking a full dose of the medicine.
If you vomit within an hour after taking Azit®, contact your doctor immediately. Your doctor will tell you if you need to take a different dose. Do not take another dose unless your doctor tells you to do so.
You should start feeling better during the first few days of azithromycin treatment. If your symptoms don’t improve or worsen, call your doctor.
Take Azit® until the amount indicated in the prescription is finished, even if you feel better. Do not stop taking Azit® unless you experience serious side effects described in the Side effects section. If you stop taking Azit® too early or miss doses, the infection may not fully heal and the bacteria may become resistant to antibiotics.
- temporary hearing loss,
- vomiting, diarrhea.
- gastric lavage,
- administration of activated charcoal,
- symptomatic therapy.
What should I do in case of an overdose?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has difficulty breathing, or is unable to wake up, call emergency services immediately at 911.
- In a dry place, protected from light, at a temperature not exceeding 25°C.
- The drug should be kept out of the reach of children.
2 years. Do not use after the expiration date.
Indications for the use of Azit® antibiotic
Infectious and inflammatory diseases caused by Acic®-sensitive pathogens:
- infections of the upper respiratory tract and ENT organs (angina, sinusitis, tonsillitis, otitis media);
- scarlet fever;
- infection of the lower respiratory tract (bacterial and typical pneumonia, bronchitis);
- infections of the skin and soft tissues (erysipelas, impetigo, secondarily infected dermatoses).
- infections of the urogenital tract (uncomplicated urethritis and/or cervicitis);
- Lyme disease (borreliosis), for the treatment of the initial stage (erythema migrans);
- diseases of the stomach and duodenum associated with Helicobacter Pylori.
Contraindications for Azit® tablets
- Hypersensitivity to macrolide antibiotics,
- severe liver and kidney dysfunction,
- children under 12 years of age and weighing less than 45 kg (for 500 mg capsules),
- children under 3 years of age (for capsules),
- pregnancy and lactation.
Side effects that Azit® may cause Azithromycin
Azit® may cause side effects. Talk to your doctor about eating grapefruit (Grapefruit) and drinking grapefruit juice while taking Azit®.
- vomiting abdominal
- pain headache
Some side effects of Azithromycin can be serious. If you experience any of these symptoms, stop taking azithromycin and contact your doctor immediately or seek emergency medical attention.:
- rapid heart rate, rapid heartbeat or slow
- rash with or without fever
- blisters or peeling
- fever and soreness, like blisters that are filled with pus (damage), in areas of swelling and redness on the skin
- difficulty breathing or swallowing
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles or lower leg
- vomiting and irritability during feeding (children less than 6 weeks)
- severe diarrhea (loose stools or blood) that may occur with or without fever and stomach cramps (this may occur up to 2 months or more after treatment)
- the jaundice of the skin or eyes
- excessive fatigue
- unusual bruising or bleeding
- lack of energy
- loss of appetite
- pain in the right upper abdomen flu
- dark urine
- muscle weakness, unusual or difficult to control muscles
- conjunctivitis and inflammation of the eyes
Azithromycin can lead to other side effects. Call your doctor if you have any unusual problems while taking this medicine.
- 1 Azit® 250 / 500 mg For The Treatment of Various Bacterial Infections – Overview
- 2 How should azithromycin drug Azit® be used?
- 3 Indications for the use of Azit® antibiotic
- 4 Contraindications for Azit® tablets
- 5 Side effects that Azit® may cause Azithromycin